PRIMARY STUDY
Involvement of spinal G-protein inwardly rectifying potassium (GIRK) channels in the enhanced antinociceptive effects of the activation of both μ-opioid and cannabinoid CB1 receptors
Key Findings: The resulting data suggests that co-administration of MOR and CB1 agonists may enhance their antinociceptive effects.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Japan
Year of Pub: 2022
Cannabinoids Studied: CP-x Synthetic Cannabinoids, WIN-x Synthetic Cannabinoids
Phytocannabinoid Source: Not Applicable
Receptors Studied: CB1, Opioid Receptor Mu , CB1 agonist
Ligands Studied: Endogenous opioids
Citation: Takemura Y, et al. Involvement of spinal G-protein inwardly rectifying potassium (GIRK) channels in the enhanced antinociceptive effects of the activation of both μ-opioid and cannabinoid CB1 receptors. J Pharmacol Sci. 2022; 149:85-92. doi: 10.1016/j.jphs.2022.04.002
Authors: Takemura Y, Sudo Y, Saeki T, Kurata S, Suzuki T, Mori T, Uezono Y
