PRIMARY STUDY

Changes in the expression of endocannabinoid system components in an experimental model of chemotherapy-induced peripheral neuropathic pain: Evaluation of sex-related differences

Key Findings:  Oxaliplatin administration in rats led to significant changes in the endocannabinoid system (ECS) including cannabinoid receptors, ligands, and enzymes mostly in the peripheral nervous system. Differences were also noted between both sexes. This research may provide a better understanding of oxaliplatin-induced peripheral neuropathy and lead to better therapeutic targets for treatment.