PRIMARY STUDY

Effects of combined CBGA and cannabis-derived terpene nanoformulations on TRPV1 activation: Implications for enhanced pain management

Key Findings:  This study found that combining encapsulated cannabigerolic acid (CBGA) nanoparticles (NPs) with terpene-loaded NPs could enhance the pain-relieving properties of CBGA. These results present a promising novel strategy for advanced pain therapeutics.

Type of Study:  Laboratory Study

Study Result:  Positive

Research Location(s):  Spain, United States

Year of Pub:  2025


Cannabinoids Studied:  Cannabigerolic Acid (CBG-a)

Phytocannabinoid Source:  Not Applicable

Terpenes Studied:  ß-Caryophyllene, Myrcene, Nerolidol

Receptors Studied:  TRPV1




Citation:  El-Hammadi MM, Small-Howard AL, Fernández-Arévalo M, Turner H, Martín-Banderas L. Effects of combined CBGA and cannabis-derived terpene nanoformulations on TRPV1 activation: Implications for enhanced pain management. Int J Pharm. 2025 Jun 30;679:125766. doi: 10.1016/j.ijpharm.2025.125766. Epub 2025 May 24. PMID: 40419035.