PRIMARY STUDY
Role of peroxisome proliferator-activated receptors α and γ in mediating the beneficial effects of β-caryophyllene in a rat model of fragile X syndrome
Key Findings: In this rat model of Fragile X Syndrome, both acute and repeated administration of β-Caryophyllene (BCP) improved cognition. These effects were mediated by activation of hippocampal peroxisome proliferator-activated receptors (PPARs) α and γ.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Italy
Year of Pub: 2025
Cannabinoids Studied: Endocannabinoid (unspecified)
Phytocannabinoid Source: Not Applicable
Terpenes Studied: ß-Caryophyllene
Receptors Studied: PPAR - Alpha, PPAR - Gamma, PPARs
Citation: Rava A, Buzzelli V, Feo A, Ascone F, Di Trapano M, Schiavi S, Carbone E, Pasquadibisceglie A, Polticelli F, Manduca A, Trezza V. Role of peroxisome proliferator-activated receptors α and γ in mediating the beneficial effects of β-caryophyllene in a rat model of fragile X syndrome. Prog Neuropsychopharmacol Biol Psychiatry. 2025 Jan 10;136:111234. doi: 10.1016/j.pnpbp.2024.111234. Epub 2024 Dec 24. PMID: 39725014.
