PRIMARY STUDY
Effects of a cannabidiol/terpene formulation on sleep in individuals with insomnia: a double-blind, placebo-controlled, randomized, crossover study
Key Findings: Select cannabidiol(CBD)- terpene ratios increase slow wave sleep (SWS) and rapid eye movement ( REM) in some individuals with insomnia and maight be a safe and efficacious alternative to over-the-counter (OTC) and prescribed sleep medications.
Type of Study: Double Blind Clinical Trial
Study Sample Size: 125
Study Result: Positive
Research Location(s): United States
Year of Pub: 2024
Cannabinoids Studied: Cannabidiol (CBD), Pharma CBD
Phytocannabinoid Source: Not Applicable
Terpenes Studied: ß-Caryophyllene, Limonene, Linalool, Myrcene, Phytol, Pinene, Terpineol, Terpinolene
DOSING DETAILS 
Study Dosing Objective: Effective Dose
Established Protocol: Effective dose
Route of Administration: Oral (Ingestion)
Cannabinoid Ratio: (CBD) 1 
Dosing Regimen: CBD (300 mg) and terpenes (1 mg each of linalool, myrcene, phytol, limonene, α-terpinene, α-terpineol, α-pinene, and β-caryophyllene) for ≥ 4 days/week
Treatment Duration: 4 weeks
Clinical Relevance: CBD + specific terpenes may improve the quality of sleep.
Additional Notes: Cross-Over
Citation: Wang M, et al. Effects of a cannabidiol/terpene formulation on sleep in individuals with insomnia: a double-blind, placebo-controlled, randomized, crossover study. J Clin Sleep Med. 2025; 21:69-80. doi: 10.5664/jcsm.11324
Authors: Wang M, Faust M, Abbott S, Patel V, Chang E, Clark JI, Stella N, Muchowski PJ
