PRIMARY STUDY
β-caryophyllene, a dietary cannabinoid, complexed with β-cyclodextrin produced anti-hyperalgesic effect involving the inhibition of Fos expression in superficial dorsal horn
Key Findings: β-caryophyllene with β-cyclodextrin attenuates the non-inflammatory chronic muscle pain in mice and inhibits the Fos expression in the lumbar spinal cord.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Brazil, United States
Year of Pub: 2016
Cannabinoids Studied:
Phytocannabinoid Source: Not Applicable
Terpenes Studied: ß-Caryophyllene
DOSING DETAILS 
Study Dosing Objective: Effective Dose
Established Protocol: Effective dose
Route of Administration: Oral (Ingestion)
Dosing Regimen: β-caryophyllene (βCP) and β-cyclodextrin (βCP-βCD) 10 or 20mg/kg/day
Treatment Duration: 9 days
Additional Notes: Pharmacodynamic Study Data, Parallel Dose Comparison
Citation: Quintans-Júnior LJ, et al. β-caryophyllene, a dietary cannabinoid, complexed with β-cyclodextrin produced anti-hyperalgesic effect involving the inhibition of Fos expression in superficial dorsal horn. Life Sci. 2016; 149:34-41. doi: 10.1016/j.lfs.2016.02.049
Authors: Quintans-Júnior LJ, Araújo AA, Brito RG, Santos PL, Quintans JS, Menezes PP, Serafini MR, Silva GF, Carvalho FM, Brogden NK, Sluka KA
