PRIMARY STUDY

Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception.

Key Findings:  The present results demonstrate that antinociception produced by i.pl. BCP is mediated by activation of CB2 receptors, which stimulates the local release from keratinocytes of the endogenous opioid β-endorphin. The combined injection of morphine and BCP may be an alternative in treating chemogenic pain.