PRIMARY STUDY
Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception.
Key Findings: The present results demonstrate that antinociception produced by i.pl. BCP is mediated by activation of CB2 receptors, which stimulates the local release from keratinocytes of the endogenous opioid β-endorphin. The combined injection of morphine and BCP may be an alternative in treating chemogenic pain.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Japan
Year of Pub: 2013
Cannabinoids Studied: AM-x Synthetic Cannabinoids
Phytocannabinoid Source: Not Applicable
Terpenes Studied: ß-Caryophyllene
Receptors Studied: CB2
Ligands Studied: Endogenous opioids
Route of Administration: Injection
Citation: Katsuyama S, et al. Involvement of peripheral cannabinoid and opioid receptors in β-caryophyllene-induced antinociception. Eur J Pain. 2013; 17:664-75. doi: 10.1002/j.1532-2149.2012.00242.x
Authors: Katsuyama S, Mizoguchi H, Kuwahata H, Komatsu T, Nagaoka K, Nakamura H, Bagetta G, Sakurada T, Sakurada S
