PRIMARY STUDY

Use of caryophyllene oxide as an antifungal agent in an in vitro experimental model of onychomycosis.

Key Findings:  Caryophyllene oxide, an oxygenated terpenoid, well known as preservative in food, drugs and cosmetics, has been tested in vitro as an antifungal against dermatophytes. Its antifungal activity has been compared to ciclopiroxolamine and sulconazole, commonly used in onychomycosis treatment and chosen because of their very different chemical structures.