Key Findings:  This case study of 4 individuals and the efficacy and safety of cannabidiol as an adjunct therapy in the treatment of anxiety-related disorders finds cannabidiol (CBD) is safe and effective when combined with cognitive therapies.
Type of Study:  Meta-analysis
Study Sample Size:  4
Study Result:  Positive
Research Location(s):  Mexico
Year of Pub:  2022
Cannabinoids Studied:  Cannabidiol (CBD), Anandamide (AEA), Fatty Acid Amide Hydrolase (FAAH), 2-Arachidonoyl Glycerol (2-AG), Monoacylglycerol Lipase (MAGL), Endocannabinoid (unspecified)
Phytocannabinoid Source:  Isolate
Chemotype:  Chemotype III
Terpenes Studied:  ß-Caryophyllene, Borneol
Receptors Studied:  CB1, CB2, GPCR 3, GPCR 6, GPCR 18, GPCR 55, TRPA1, TRPV1, TRPV2, TRPV4, PPAR - Gamma, GPCR
Ligands Studied:  GABA, Glutamate, Serotonin
DOSING DETAILS   
Study Dosing Objective:  Effective Dose, Safety Profile
Established Protocol:  Effective dose
Route of Administration:  Oral (Ingestion)
Cannabinoid Ratio:  (CBD)   0    
Dosing Regimen:  CBD (20–80 mg/day)
Maximum Dose:  80 mg/day
Citation:  Ortiz Rios FC, et al. Cannabidiol as a personalized treatment for anxiety: clinical cases in Mexico. Drugs Context. 2022; 11:(unknown pages). doi: 10.7573/dic.2022-3-2
Authors:  Ortiz Rios FC, Dávila Ruiz IG, Sacal Dumani E