PRIMARY STUDY
Cannabis sativa Extract Induces Apoptosis in Human Pancreatic 3D Cancer Models: Importance of Major Antioxidant Molecules Present Therein
Key Findings: When human pancreatic tumor cell lines were exposed to medicinal hemp, cannabidiol dominant, it led to an increase in superoxide ions, altering the membrane potential, inducing the cell cycle arrest, and eventually leading to cell death.
Type of Study: Laboratory Study
Study Result: Positive
Study Location(s): France
Year of Pub: 2022
Cannabinoids Studied: Cannabichromene (CBC), Cannabidiol (CBD), Cannabigerol (CBG), Tetrahydrocannabinol (THC), Cannabinol (CBN), Cannabichromenic Acid (CBC-a), Cannabidiolic Acid (CBD-a), Cannabigerolic Acid (CBG-a), Tetrahydrocannabinolic Acid (THC-a), Tetrahydrocannabivarin (THCV), Delta-8-THC
Phytocannabinoid Source: Cannabis Flower derived
Chemotype: Chemotype III
Terpenes Studied: ß-Caryophyllene, Borneol, Linalool, Myrcene, Terpineol
Receptors Studied: CB1, CB2, GPCR
Ligands Studied: Pro-inflammatory cytokines
Sub-Ratio: THC:CBD 1:15