PRIMARY STUDY
Beta-caryophyllene prevents the defects in trabecular bone caused by Vitamin D deficiency through pathways instated by increased expression of klotho
Key Findings: This mouse study found that diets enhanced with β-caryophyllene (BCP) led to elevated levels of klotho which in mice improves bone volume and density. In mice klotho also regulates CB1 and fibroblast growth factors.
Type of Study: Animal Study
Study Sample Size: 40
Study Result: Positive
Research Location(s): United States
Year of Pub: 2022
Cannabinoids Studied:
Phytocannabinoid Source: Unspecified
Terpenes Studied: ß-Caryophyllene
Receptors Studied: CB1, CB2
Route of Administration: Oral (Ingestion)
Citation: Dong W, et al. Beta-caryophyllene prevents the defects in trabecular bone caused by Vitamin D deficiency through pathways instated by increased expression of klotho. Bone Joint Res. 2022; 11:528-540. doi: 10.1302/2046-3758.118.BJR-2021-0392.R1
Authors: Dong W, Postlethwaite BC, Wheller PA, Brand D, Jiao Y, Li W, Myers LK, Gu W
