PRIMARY STUDY
Role of Caryophyllane Sesquiterpenes in the Entourage Effect of Felina 32 Hemp Inflorescence Phytocomplex in Triple Negative MDA-MB-468 Breast Cancer Cells
Key Findings: This study of triple-negative breast cancer cells found that two phytocannabinoids, cannabidiol and cannabichromene, and 2 caryophyllane sesquiterpenes, had anti-cancer activity against these cells and findings suggest that phytocannabinoids and terpenes may play a role in these anti-cancer effects and warrant further research.
Type of Study: Laboratory Study
Study Result: Positive
Research Location(s): Italy
Year of Pub: 2022
Cannabinoids Studied: Cannabichromene (CBC), Cannabidiol (CBD)
Phytocannabinoid Source: Hemp derived
Chemotype: Chemotype III
Terpenes Studied: ß-Caryophyllene, Humulene
Receptors Studied: CB1, CB2
Citation: Di Giacomo S, et al. Role of Caryophyllane Sesquiterpenes in the Entourage Effect of Felina 32 Hemp Inflorescence Phytocomplex in Triple Negative MDA-MB-468 Breast Cancer Cells. Molecules. 2021; 26:(unknown pages). doi: 10.3390/molecules26216688
Authors: Di Giacomo S, Mariano A, Gullì M, Fraschetti C, Vitalone A, Filippi A, Mannina L, Scotto d'Abusco A, Di Sotto A
