Key Findings:  This study found that caryophyllene oxide causes significant depression of the central nervous system (CNS) in mice in this model of insomnia and CNS-related disorders.
Type of Study:  Animal Study
Study Result:  Inconclusive
Research Location(s):  Japan
Year of Pub:  2021
Cannabinoids Studied:  Other Related Compounds
Phytocannabinoid Source:  Not Applicable
Terpenes Studied:  ß-Caryophyllene
Ligands Studied:  GABA
Citation:  Dougnon G and Ito M. Essential Oil from the Leaves of Chromolaena odorata, and Sesquiterpene Caryophyllene Oxide Induce Sedative Activity in Mice. Pharmaceuticals (Basel). 2021; 14:(unknown pages). doi: 10.3390/ph14070651
Authors:  Dougnon G, Ito M