PRIMARY STUDY
Analgesic Potential of Terpenes Derived from Cannabis sativa
Key Findings: This review discusses the current knowledge of cannabis terpenes in both human and animal research. Although large sample and human-controlled trials are limited, there appears to be potential therapeutic use in pain management with relative safety with few side effects and toxicities reported.
Type of Study: Meta-analysis
Study Result: Positive
Research Location(s): United States
Year of Pub: 2021
Cannabinoids Studied: Cannabidiol (CBD), Tetrahydrocannabinol (THC), Cannabinoid (unspecified)
Phytocannabinoid Source: Unspecified
Terpenes Studied: ß-Caryophyllene, Camphene, Eucalyptol, Geraniol, Humulene, Limonene, Linalool, Myrcene, Nerolidol, Ocimene, Pinene, Terpineol, Terpinolene
Receptors Studied: CB1, CB2, GPCR 55, TRPA1, TRPV1, GPCR, TRPs
Ligands Studied: Anti-inflammatory cytokines, Dopamine, Norepinephrine, Pro-inflammatory cytokines
Citation: Liktor-Busa E, et al. Analgesic Potential of Terpenes Derived from Cannabis sativa. Pharmacol Rev. 2021; 73:98-126. doi: 10.1124/pharmrev.120.000046
Authors: Liktor-Busa E, Keresztes A, LaVigne J, Streicher JM, Largent-Milnes TM
