PRIMARY STUDY
Viphyllin TM, a Standardized Black Pepper Seed Extract Exerts Antinociceptive Effects in Murine Pain Models via Activation of Cannabinoid Receptor CB2, Peroxisome Proliferator-Activated Receptor-Alpha and TRPV1 Ion Channels
Key Findings: A standardized black pepper seed extract (i.e., Viphyllin) containing not less than 30% β-caryophyllene may be a safer analgesic compound then opiates or NSAIDs.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): India
Year of Pub: 2022
Cannabinoids Studied:
Phytocannabinoid Source: Not Applicable
Terpenes Studied: ß-Caryophyllene
Receptors Studied: CB2, TRPV1, PPAR - Alpha
Route of Administration: Injection
Citation: Venkatakrishna K, et al. ViphyllinTM, a Standardized Black Pepper Seed Extract Exerts Antinociceptive Effects in Murine Pain Models via Activation of Cannabinoid Receptor CB2, Peroxisome Proliferator-Activated Receptor-Alpha and TRPV1 Ion Channels. J Pain Res. 2022; 15:355-366. doi: 10.2147/JPR.S351513
Authors: Venkatakrishna K, Sundeep K, Sudeep HV, Gouthamchandra K, Shyamprasad K
