PRIMARY STUDY
Potentiating Effect Of Beta-caryophyllene On Anticancer Activity Of Alpha-humulene, Isocaryophyllene And Paclitaxel
Key Findings: Tested on MCF-7 (Study results suggest that beta-caryophyllene, tested on MCF-7 (breast cancer cells) and DLD-1 (colon cancer cells), facilitates the passage of paclitaxel through the membrane and thus potentiates its anticancer activity. The highest potentiating effect was obtained in DLD-1 cells treated with paclitaxel combined with 10 microg mL(-1) beta-caryophyllene, which increased the paclitaxel activity about 10-fold.
Type of Study: Laboratory Study
Study Result: Positive
Research Location(s): Canada
Year of Pub: 2007
Cannabinoids Studied:
Phytocannabinoid Source: Not Applicable
Terpenes Studied: ß-Caryophyllene, Humulene
Route of Administration: In vitro
Citation: Legault J and Pichette A. Potentiating effect of beta-caryophyllene on anticancer activity of alpha-humulene, isocaryophyllene and paclitaxel. J Pharm Pharmacol. 2007; 59:1643-7. doi: 10.1211/jpp.59.12.0005
Authors: Legault J, Pichette A
