PRIMARY STUDY

Antinociceptive and chondroprotective effects of prolonged β-caryophyllene treatment in the animal model of osteoarthritis: Focus on tolerance development

Key Findings:  Injection of BCP inhibited cartilage degeneration without producing tolerance for the analgesic effects. Furthermore, BCP was able to produce both acute and chronic antinociceptive and chondroprotective effects. As such, the authors posit that given the excellent safety profile and legal status of BCP, these results indicate a novel and promising disease-modifying strategy for treating OA.