PRIMARY STUDY

b-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation.

Key Findings:  Research findings suggest that b-Caryophyllene oxide can interfere with multiple signaling cascades involved in tumorigenesis and used as a potential therapeutic candidate for both the prevention and treatment of cancer.

Type of Study:  Laboratory Study

Study Result:  Positive

Research Location(s):  Singapore, South Korea

Year of Pub:  2011


Cannabinoids Studied: 

Phytocannabinoid Source:  Not Applicable

Terpenes Studied:  ß-Caryophyllene

Route of Administration:  In vitro




Citation:  Park KR, et al. β-Caryophyllene oxide inhibits growth and induces apoptosis through the suppression of PI3K/AKT/mTOR/S6K1 pathways and ROS-mediated MAPKs activation. Cancer Lett. 2011; 312:178-88. doi: 10.1016/j.canlet.2011.08.001

Authors:  Park KR, Nam D, Yun HM, Lee SG, Jang HJ, Sethi G, Cho SK, Ahn KS