PRIMARY STUDY
β-Caryophyllene Ameliorates MSU-Induced Gouty Arthritis and Inflammation Through Inhibiting NLRP3 and NF-κB Signal Pathway: In Silico and In Vivo
Key Findings: β-caryophyllene significantly reduced inflammation in monosodium urate crystals-induced gouty arthritis in test animals. More specifically, effects were associated with decreasing serum cytokine levels and by inhibiting expressions of NLRP3, Caspase-1, ASC, TLR4, MyD88, p65, and IL-1β.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): China, South Korea
Year of Pub: 2021
Cannabinoids Studied:
Phytocannabinoid Source: Not Applicable
Terpenes Studied: ß-Caryophyllene
Receptors Studied: CB2
Ligands Studied: Anti-inflammatory cytokines, Pro-inflammatory cytokines
Citation: Li WY, et al. β-Caryophyllene Ameliorates MSU-Induced Gouty Arthritis and Inflammation Through Inhibiting NLRP3 and NF-κB Signal Pathway: In Silico and In Vivo. Front Pharmacol. 2021; 12:651305. doi: 10.3389/fphar.2021.651305
Authors: Li WY, Yang F, Chen JH, Ren GF
