PRIMARY STUDY

β-caryophyllene ameliorated obesity-associated airway hyperresponsiveness through some non-conventional targets

Key Findings:  Obesity-associated airway hyperresponsiveness is ameliorated by administration of BCP. More specifically, these effects were initiated via the inhibition of macrophage polarization, by activation of AMPKα, Nrf2/HO-1 and AdipoR1 and AdipoR2 signaling pathway, by up-regulation of adiponectin, GLP-1, IFN-γ, SOD, catalase and by down-regulation of NF-κB, leptin, IL-4, TNF, and IL-1β.