PRIMARY STUDY
The cannabinoid 2 receptor agonist β-caryophyllene modulates the inflammatory reaction induced by Mycobacterium bovis BCG by inhibiting neutrophil migration.
Key Findings: These results suggest that the CB2 receptor may represent a new target for modulating the inflammatory reaction induced by mycobacteria.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Brazil
Year of Pub: 2016
Cannabinoids Studied:
Terpenes Studied: ß-Caryophyllene
Receptors Studied: CB2
Dosage: BCP (0.5-50 mg/kg) or intraperitonealy with GP1a (10 mg/kg) 1 h before the induction of pleurisy or pulmonary inflammation by BCG.
Route of Administration: Injection, Oral (Ingestion)
Citation: Andrade-Silva M, et al. The cannabinoid 2 receptor agonist β-caryophyllene modulates the inflammatory reaction induced by Mycobacterium bovis BCG by inhibiting neutrophil migration. Inflamm Res. 2016; 65:869-879. doi: 10.1007/s00011-016-0969-3
Authors: Andrade-Silva M, Correa LB, Candéa AL, Cavalher-Machado SC, Barbosa HS, Rosas EC, Henriques MG
