PRIMARY STUDY
Terpenoids From Cannabis Do Not Mediate an Entourage Effect by Acting at Cannabinoid Receptors
Key Findings: This study did not find that terpenes have direct interactions with CB1 or CB2 receptors. The radioligand ([3H]-CP55,940), THC, and CBD were not changed by the presence of terpenes. This study was not able to explain the synergistic effects of cannabis compounds and CB1 or CB2 receptors.
Type of Study: Laboratory Study
Study Result: Negative
Research Location(s): New Zealand
Year of Pub: 2020
Cannabinoids Studied: Cannabidiol (CBD), Tetrahydrocannabinol (THC), 2-Arachidonoyl Glycerol (2-AG)
Phytocannabinoid Source: Cannabis Flower derived
Terpenes Studied: ß-Caryophyllene, Limonene, Myrcene, Pinene
Receptors Studied: CB1, CB2
Route of Administration: In vitro
Citation: Finlay DB, et al. Terpenoids From Cannabis Do Not Mediate an Entourage Effect by Acting at Cannabinoid Receptors. Front Pharmacol. 2020; 11:359. doi: 10.3389/fphar.2020.00359
Authors: Finlay DB, Sircombe KJ, Nimick M, Jones C, Glass M
