PRIMARY STUDY
The Effects of Selected Sesquiterpenes from Myrica rubra Essential Oil on the Efficacy of Doxorubicin in Sensitive and Resistant Cancer Cell Lines
Key Findings: Only nerolidol showed a degree of synergism in all cell lines where it was possible to test for it. The effect from the combination of DOX with sesquiterpenes was not different from the effect of sesquiterpenes alone in the CEM/ADR cell line, despite the appearance of the largest shift of intracellular DOX concentrations. Further tests suggested the interaction of sesquiterpenes with efflux transporters as the possible mechanism of synergism with DOX.
Type of Study: Laboratory Study
Study Result: Positive
Research Location(s): Czech Republic
Year of Pub: 2017
Cannabinoids Studied:
Phytocannabinoid Source: Not Applicable
Terpenes Studied: ß-Caryophyllene, Humulene, Nerolidol
Route of Administration: In vitro
Citation: Ambrož M, et al. The Effects of Selected Sesquiterpenes from Myrica rubra Essential Oil on the Efficacy of Doxorubicin in Sensitive and Resistant Cancer Cell Lines. Molecules. 2017; 22:(unknown pages). doi: 10.3390/molecules22061021
Authors: Ambrož M, Matoušková P, Skarka A, Zajdlová M, Žáková K, Skálová L
