PRIMARY STUDY
The cannabinoid receptor 2 agonist, β-caryophyllene, improves working memory and reduces circulating levels of specific proinflammatory cytokines in aged male mice
Key Findings: Based on previously discovered properties of β-caryophyllene (BCP) to induce its anti-inflammatory effects, improve memory and an increase lifespan for example these researchers confirmed that deficits in working memory and an age-related increase in pro-inflammatory cytokines were both reversed by BCP.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): United States
Year of Pub: 2019
Cannabinoids Studied:
Phytocannabinoid Source: Not Applicable
Terpenes Studied: ß-Caryophyllene
Receptors Studied: CB2
Ligands Studied: Anti-inflammatory cytokines
DOSING DETAILS 
Study Dosing Objective: Effective Dose
Established Protocol: Effective dose
Dosing Regimen: β-caryophyllene 100–300 mg/kg
Clinical Relevance: β-caryophyllene improved working memory and decreased IL-23 levels in aged mice and appears to reverse age-associated impairments in memory and modulate cytokine production.
Citation: Lindsey LP, et al. The cannabinoid receptor 2 agonist, β-caryophyllene, improves working memory and reduces circulating levels of specific proinflammatory cytokines in aged male mice. Behav Brain Res. 2019; 372:112012. doi: 10.1016/j.bbr.2019.112012
Authors: Lindsey LP, Daphney CM, Oppong-Damoah A, Uchakin PN, Abney SE, Uchakina ON, Khusial RD, Akil A, Murnane KS
