PRIMARY STUDY
Acute administration of beta-caryophyllene prevents endocannabinoid system activation during transient common carotid artery occlusion and reperfusion.
Key Findings: Collectively, the pre-treatment with BCP, likely acting as agonist for CB2 and PPAR-alpha receptors, modulates in a beneficial way the ECS activation and the lipoperoxidation, taken as indicative of oxidative stress. Furthermore, results support the evidence that BCP may be used as a dietary supplement to control the physiological response to the hypoperfusion/reperfusion-induced oxidative stress.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Italy
Year of Pub: 2018
Cannabinoids Studied:
Terpenes Studied: ß-Caryophyllene
Receptors Studied: CB2, PPAR - Alpha
Dosage: β-caryophyllene (40 mg/per rat in 300 μl of sunflower oil as vehicle) 6 h before surgery
Route of Administration: Oral (Ingestion)
Citation: Poddighe L, et al. Acute administration of beta-caryophyllene prevents endocannabinoid system activation during transient common carotid artery occlusion and reperfusion. Lipids Health Dis. 2018; 17:23. doi: 10.1186/s12944-018-0661-4
Authors: Poddighe L, Carta G, Serra MP, Melis T, Boi M, Lisai S, Murru E, Muredda L, Collu M, Banni S, Quartu M
