PRIMARY STUDY
β-Caryophyllene Ameliorates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis through the Downregulation of Mitogen-Activated Protein Kinase/EGR1/TSLP Signaling Axis
Key Findings: This study demonstrates that topical β-caryophyllene ameliorates atopic dermatitis–like skin inflammation in mice by suppressing MAPK/EGR1-mediated TSLP expression and reducing proinflammatory cell infiltration, supporting its potential as a CB2-targeted therapeutic for chronic inflammatory skin disease.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): South Korea
Year of Pub: 2026
Cannabinoids Studied:
Phytocannabinoid Source: Not Applicable
Terpenes Studied: ß-Caryophyllene
Receptors Studied: CB2, CB2 agonist
Ligands Studied: Pro-inflammatory cytokines
Route of Administration: , Topical
Citation: Ahn SS, Yeo H, Jung E, Ou S, Lee YH, Lim Y, Shin SY. β-Caryophyllene Ameliorates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis through the Downregulation of Mitogen-Activated Protein Kinase/EGR1/TSLP Signaling Axis. Int J Mol Sci. 2022 Nov 28;23(23):14861. doi: 10.3390/ijms232314861. PMID: 36499191; PMCID: PMC9740728.
