PRIMARY STUDY
Neuropathic Pain and Related Depression in Mice: The Effect of a Terpene and a Minor Cannabinoid in Combination
Key Findings: Looking at the effects of a combination of Beta-Caryophyllene (BCP) and cannabidiol (CBD) on neuropathic pain and depression-like behaviors in mice, this study found synergistic neuropathic pain relief and an antidepressant effect.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): United States
Year of Pub: 2025
Cannabinoids Studied: Cannabidiol (CBD), Cannabinoid (unspecified), Pharma CBD
Phytocannabinoid Source: Not Applicable
Terpenes Studied: ß-Caryophyllene
Citation: Rios J, Alnoud M, Hussain MS, Ayas Z, Franco E, Mills J, Nwose J, Malbas MS, Garcia H, Tripathi MK, Benamar K. Neuropathic Pain and Related Depression in Mice: The Effect of a Terpene and a Minor Cannabinoid in Combination. Biomedicines. 2025 Dec 16;13(12):3103. doi: 10.3390/biomedicines13123103. PMID: 41463111; PMCID: PMC12730619.
