PRIMARY STUDY
β-Caryophyllene/Hydroxypropyl-β-Cyclodextrin Inclusion Complex Improves Cognitive Deficits in Rats with Vascular Dementia through the Cannabinoid Receptor Type 2 -Mediated Pathway
Key Findings: This study shows that a β-caryophyllene–hydroxypropyl-β-cyclodextrin inclusion complex enhances β-caryophyllene bioavailability and ameliorates cognitive deficits in vascular dementia rats by improving cerebral blood flow and activating CB2-mediated PI3K/Akt signaling pathways.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): China
Year of Pub: 2026
Cannabinoids Studied:
Phytocannabinoid Source: Not Applicable
Terpenes Studied: ß-Caryophyllene
Route of Administration: , Injection
Citation: Lou J, Teng Z, Zhang L, Yang J, Ma L, Wang F, Tian X, An R, Yang M, Zhang Q, Xu L, Dong Z. β-Caryophyllene/Hydroxypropyl-β-Cyclodextrin Inclusion Complex Improves Cognitive Deficits in Rats with Vascular Dementia through the Cannabinoid Receptor Type 2 -Mediated Pathway. Front Pharmacol. 2017 Jan 19;8:2. doi: 10.3389/fphar.2017.00002. PMID: 28154534; PMCID: PMC5243824.
