PRIMARY STUDY
Therapeutic potential of cannabidiol-rich Cannabis sativa to mitigate the severity of inflammation and pain: A pre-clinical study
Key Findings: In this animal model of pain and inflammation CBD, CBDA, and Δ9-THC were major cannabinoids in the cannabis sativa genotype CIM-CS-64 (CSFE), which markedly reduced the production of pro-inflammatory cytokines without causing any cytotoxicity.
Type of Study: Animal Study
Study Sample Size: 62
Study Result: Positive
Research Location(s): India
Year of Pub: 2025
Cannabinoids Studied: Cannabichromene (CBC), Cannabidiol (CBD), Tetrahydrocannabinol (THC), Cannabidiolic Acid (CBD-a), Cannabidivarin (CBDV)
Phytocannabinoid Source: Not Applicable
Terpenes Studied: ß-Caryophyllene, Phytol, Bisabolol
Ligands Studied: Pro-inflammatory cytokines
Citation: Singh MK, Sen S, Singh S, Aftab N, Kumar B, Gupta N, Tandon S, Bawankule DU, Verma RS. Therapeutic potential of cannabidiol-rich Cannabis sativa to mitigate the severity of inflammation and pain: A pre-clinical study. J Ethnopharmacol. 2026 Feb 28;357:120856. doi: 10.1016/j.jep.2025.120856. Epub 2025 Nov 8. PMID: 41213439.
