PRIMARY STUDY
Anticonvulsant activity of β-caryophyllene against pentylenetetrazol-induced seizures.
Key Findings: The present data suggest that β-caryophyllene displays anticonvulsant activity against seizures induced by PTZ in mice. Since no adverse effects were observed in the same dose range of the anticonvulsant effect, β-caryophyllene should be further evaluated in future development of new anticonvulsant drugs.
Type of Study: Animal Study
Study Result: Positive
Research Location(s): Brazil
Year of Pub: 2016
Cannabinoids Studied:
Phytocannabinoid Source: Not Applicable
Terpenes Studied: ß-Caryophyllene
DOSING DETAILS 
Study Dosing Objective: Effective Dose
Established Protocol: Effective dose
Route of Administration: Injection
Dosing Regimen: β-caryophyllene (0, 10, 30, or 100 mg/kg) β-caryophyllene (100 mg/kg) improved recognition index
Starting Dose: 0 mg/kg
Maximum Dose: 100 mg/kg
Clinical Relevance: In mice β-Caryophyllene increased latency to PTZ-induced myoclonic seizures
Adverse Events: none
Citation: de Oliveira CC, et al. Anticonvulsant activity of β-caryophyllene against pentylenetetrazol-induced seizures. Epilepsy Behav. 2016; 56:26-31. doi: 10.1016/j.yebeh.2015.12.040
Authors: de Oliveira CC, de Oliveira CV, Grigoletto J, Ribeiro LR, Funck VR, Grauncke AC, de Souza TL, Souto NS, Furian AF, Menezes IR, Oliveira MS
