PRIMARY STUDY
Phytochemical Modulators of Nociception: A Review of Cannabis Terpenes in Chronic Pain Syndromes
Key Findings: This narrative review synthesizes preclinical and emerging clinical evidence on Cannabis sativa–derived terpenes, highlighting their analgesic and anti-inflammatory mechanisms, potential synergy with cannabinoids, and the need for standardized formulations and rigorous clinical studies to advance their therapeutic application in chronic pain.
Type of Study: Meta-analysis
Study Result: Positive
Research Location(s): Italy
Year of Pub: 2025
Cannabinoids Studied:
Phytocannabinoid Source: Not Applicable
Terpenes Studied: ß-Caryophyllene, Humulene, Limonene, Linalool, Myrcene, Pinene
Receptors Studied: CB2
Ligands Studied: Pro-inflammatory cytokines
Citation: Alfieri A, Di Franco S, Maffei V, Sansone P, Pace MC, Passavanti MB, Fiore M. Phytochemical Modulators of Nociception: A Review of Cannabis Terpenes in Chronic Pain Syndromes. Pharmaceuticals (Basel). 2025 Jul 24;18(8):1100. doi: 10.3390/ph18081100. PMID: 40872493; PMCID: PMC12389225.
