PRIMARY STUDY

Beta-Caryophyllene Augments Radiotherapy Efficacy in GBM by Modulating Cell Apoptosis and DNA Damage Repair via PPARγ and NF-κB Pathways

Key Findings:  In glioblastoma multiforme (GBM) cells, beta-caryophyllene (BCP) induced a deceleration of DNA damage repair, upregulated PPARγ levels, and reduced expression of pAKT, pERK, and NF-κB, causing apoptosis and inhibition of survival pathways. Results may prove BCP to be a potential radiosensitizer for improving radiotherapy outcomes in GBM.