Chemotherapy-induced nausea and vomiting (CINV) are common side effects of cancer treatment caused by the toxic effects of chemotherapy drugs on the body. The endocannabinoid system (ECS) mitigates CINV by targeting key receptors in both the brain and the gastrointestinal tract.
The CannaKeys chemotherapy-induced nausea and vomiting treatment algorithm is based on review and analysis of scientific literature and clinical expert opinion. Focused on aspects that can be controlled in the clinical setting, it is designed to be used as a tool for creating optimal cannabinoid-based therapeutics for CINV patients while managing the complexities of the endocannabinoid system.
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Evidence-based Guidelines for Cannabis Therapeutics
We offer a systematic approach that physicians and healthcare professionals can use to make evidence-based decisions when prescribing cannabis or cannabinoids to treat chemotherapy induced nausea and vomiting. Factors that can make a significant difference in optimizing patient outcomes and producing effective antiemetic effects include the choice of a primary cannabinoid, specific dosing protocols, and form of administration.
Screening Process
Includes risk assessment, possible contraindications, and potential cannabinoid-to-pharmaceutical drug interactions.
Cannabinoid Treatment Plans
Dosing protocols consider patient preference regarding cognitive changes and altered states, and include starting dose, maximum daily dose, and titration rates for primary cannabinoid.
