While anxiety can be a normal reaction to the subjective experience of stress in various settings, such as performance anxiety, psychiatric medicine identifies five primary types of anxiety disorders: generalized anxiety disorder (GAD), obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), and social anxiety disorder (SAD). Hundreds of studies have been conducted examining the involvement of all components of the ECS in the treatment context of anxiety and panic disorders. Of these, an increasing percentage are high-quality human trials, including several systematic reviews and meta-analyses of clinical trials.
The CannaKeys anxiety treatment algorithm is based on review and analysis of scientific literature and clinical expert opinion. Focused on aspects that can be controlled in the clinical setting, it is designed to be used as a tool for creating optimal cannabinoid-based therapeutics for patients with anxiety while managing the complexities of the endocannabinoid system.
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Evidence-based Guidelines for Cannabis Therapeutics
We offer a systematic approach that physicians and healthcare professionals can use to make evidence-based decisions when prescribing cannabis or cannabinoids to treat acute anxiety (fear of public speaking) and chronic anxiety disorders (GAD, OCD, PTSD, SAD). Factors that can make a significant difference in optimizing patient outcomes and producing effective anti-anxiety effects include the choice of a primary cannabinoid, specific dosing protocols, and form of administration.
Screening Process
Includes risk assessment, possible contraindications, and potential cannabinoid-to-pharmaceutical drug interactions.
Cannabinoid Treatment Plans
Dosing protocols consider patient preference regarding cognitive changes and altered states, and include starting dose, maximum daily dose, and titration rates for primary cannabinoid.
Cannabis-based Terpenes
Terpenes with therapeutic potential for the treating anxiety with links to clinical studies.
Nutraceuticals and Supplements
All relevant herbs and nutraceuticals that interact with the endocannabinoid system or the broader endocannabinoidome with clinical evidence for treating anxiety.
Microbiome and Dietary considerations
All dietary considerations and food products that engage the microbiome and interact with the endocannabinoid system or the broader endocannabinoidome with clinical evidence for treating or mitigating anxiety.
