Capsaicin (CAPS) Cannabinoid Research

Capsaicin (CAPS) Research Dashboard

12

Primary Studies

1

Related Studies

13

Total Studies

Clinical Studies

0

Clinical Meta-analyses

0

Double-blind human trials

2

Clinical human trials

Pre-Clinical Studies

9

Meta-analyses/Reviews

1

Animal studies

0

Laboratory studies

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CannaKeys has 13 studies associated with Capsaicin (CAPS).

Here is a small sampling of Capsaicin (CAPS) studies by title:


Components of the Capsaicin (CAPS) Research Dashboard

  • Top medical conditions associated with Capsaicin (CAPS)
  • Proven effects in clinical trials for Capsaicin (CAPS)
  • Receptors associated with Capsaicin (CAPS)
  • Individual study details for Capsaicin (CAPS)

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Overview - Capsaicin (CAPS)

Description of Capsaicin (CAPS)

Capsaicin is the compound that brings heat to chilli peppers. Depending on individual sensitivities and concentration topical capsaicin can be an agent to induce therapeutic or irritant effects (e.g., peper spray, pesticide).

Capsaicin itself is without color, crystalline or waxy appearances, hydrophobic, and pungent. Local and most common adverse effects may include burning sensation, reddeing of the skin), swelling, dryness, itching, and sneezing. Systemic addverse effects tend to occur more rarely but may include: slow (bradycardia) or rapid (tachycarfdia) heart rates, low or high blood pressure, allergic reactions.

Other Names:

Capsaicin
Capsaicinoid, Capsicum, Capsicum sp.

IUPAC Name: 8-Methyl-N-vanillyl-trans-6-nonenamide

Molecular Formula: C18H27NO3

Source–PubChem

Capsaicin (CAPS) Properties and Effects

FDA approved capsaicin-based topical products for:
• Musculoskeletal pain (e.g., arthritis, back pain, sprain/strain)
• Neuropathies
• Skin condition (e.g., shingles, psoriasis, pruritis)
• Prophylaxis for postoperative nausea and vomiting

In addition there are numerous off-labed applications. Of note, beside hot showers topical capsaicin preparations is the only known method to date that relieves signs and symptoms of cannabis hyperemesis syndrome. Additional off-label use with some evidence includes protate cancer.

Capsaicin (CAPS) Receptor Binding

Endocannabinoid System (ECS)
• Potential interactions with CB1

Endocannabinoidome (eCBome)
• TRPV1 agonist (i.e., an ion channel responsive to changes in temperature and acidic pH)
• A voltage-gated sodium (Na) channel blocker
• Potential negative allosteric modulator of serotonin (5-HT3) receptor sites
• Potential antagonist of L-type calcium (Ca2+) channels

Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.