Cannabinol (CBN) Research Dashboard
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As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.
CannaKeys has 99 studies associated with Cannabinol (CBN).
Here is a small sampling of Cannabinol (CBN) studies by title:
- Cannabinol inhibits oxytosis/ferroptosis by directly targeting mitochondria independently of cannabinoid receptors
- Cannabinol modulates neuroprotection and intraocular pressure: A potential multi-target therapeutic intervention for glaucoma
- Cannabinoids, Insomnia, and Other Sleep Disorders
- Cannabinol: History, Syntheses, and Biological Profile of the Greatest “Minor” Cannabinoid
- Inhibitory Effects of Cannabinoids on Acetylcholinesterase and Butyrylcholinesterase Enzyme Activities
Components of the Cannabinol (CBN) Research Dashboard
- Top medical conditions associated with Cannabinol (CBN)
- Proven effects in clinical trials for Cannabinol (CBN)
- Receptors associated with Cannabinol (CBN)
- Individual study details for Cannabinol (CBN)
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Overview - Cannabinol (CBN)
Description of Cannabinol (CBN)
Cannabinol (CBN) was discovered in 1896 (by Wood, Spivey, and Easterfield) and its chemical structure was reported in 1940 by Roger Adams.
By 2016 there were 13 members in the CBN group.
Most CBN found in cannabis plant material is due to chemical changes that naturally occur during the drying process. As THC begins to degrade over time, some of its chemical composition transforms into CBN.
Other Names:
CannabinolCannabinolum, Cannabinolo, and other supplier-based synonyms.
IUPAC Name: 6,6,9-trimethyl-3-pentylbenzo[c]chromen-1-ol
Molecular Formula: C21H26O2
Source–PubChem
Cannabinol (CBN) Properties and Effects
CBN may:
- Induce psychoactive effects (S. Loewe 1945)
- Modulate significant anti epileptic effects (J. Davis et al., 1949)
- Generate analgesia
- Anti-bacterial against MRSA
- Anti-inflammatory
- Appetite stimulant
- Promotes sedation even at low concentrations
Cannabinol (CBN) Receptor Binding
Endocannabinoid system (ECS) and CBN:
- CB1 agonist with a mean Ki ~525±308 (using human tissue data from 3 trials) (J. McPartland et al., 2007)
- CB2 agonist with a mean Ki ~168±32 (using human tissue data from 7 trials) (J. McPartland et al., 2007)
- CB1 agonist ~ten times less potent than delta-9-THC (C. Maioli et al. 2022)
- CB2 agonist (mixed results suggesting equal to ~3 times lower than delta-9-THC (C. Maioli et al. 2022)
Ki legend:
- Full/strong agonist Ki ~1-9nM
- Moderate agonist Ki ~10-99nM
- Weak agonist Ki ~100-999nM
- Very weak agonist Ki ~1,000-up nM
(The reader is reminded that a smaller Ki is associated with the strongest effects.)
Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.
Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.
