Borneol – Terpenes and Cannabinoid Research

Borneol Research Dashboard

89

Primary Studies

9

Related Studies

98

Total Studies

Clinical Studies

0

Clinical Meta-analyses

2

Double-blind human trials

1

Clinical human trials

Pre-Clinical Studies

10

Meta-analyses/Reviews

43

Animal studies

33

Laboratory studies

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CannaKeys has 98 studies associated with Borneol.

Here is a small sampling of Borneol studies by title:


Components of the Borneol Research Dashboard

  • Top medical conditions associated with Borneol
  • Proven effects in clinical trials for Borneol
  • Receptors associated with Borneol
  • Individual study details for Borneol

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Overview - Borneol

Borneol

Borneol is a minor terpene in cannabis and more abundantly found in turmeric, thyme, and ginger, for example. It is a compound frequently used in Traditional Chinese Medicine as an analgesic and was sold in pharmacies of old as a dry powder. Rowantinex is an over-the-counter terpene formula high in pinene, camphene, and borneol.

Recent research is elucidating borneol’s potential role as a drug-delivery enhancer via improved blood-brain barrier permeation of drugs for treating ischemia and Alzheimer’s Disease with synergistic effects. It may also help drugs cross mucous membranes and skin.

Borneol is thought to have anti-inflammatory, anti-oxidant, anti-apoptotic, anti-microbial, anticoagulant activities, and improve energy metabolism.

Description of Borneol and Cautions

Concentrated borneol is a pale, white, lump-like solid. Isolated borneol is very toxic with a probable oral lethal dose of 50-500 mg/kg. This is roughly one teaspoon to one ounce for a 70kg (150lb) person.–PubChem

Scent Description

Woody, camphor, herbal

Natural Sources

Turmeric, thyme, rosemary, ginger

Summary of Borneol Effects

Antibacterial (middle ear infection)

Analgesia (via TRPM8)

Improved drug delivery through blood-brain barrier (via adenosine receptors)

Rowantinex (i.e., capsules containing pinene, camphene, cineol, fenchone, borneol, and anethol) may increase the expulsion of renal stones after shock-wave lithotripsy (via antispasmodic activity on smooth muscle in animal models)

May improve cell sensitivity to anti-cancer chemotherapy and increase cerebral uptake of 5-FU for brain metastasis

Potentially improve cancer treatment outcomes (via regulating ROS-mediated oxidative damage, MAPKs and PI3K/AKT pathway in human glioma cells, and regulation of HIF-1a expression via mTORC1/eIF4E pathway)

Preclinical anti-hypertensive and vasorelaxant effects, and improves autonomic impairment and baroreflex dysfunction in mice

In combination with Tanshinol, borneol may be therapeutic for pressure overload-induced cardiac hypertrophy with anti-atherosclerotic and anti-inflammatory effects (via regulating the mTOR/β-TrcP/NRF2 signal pathway)

Ameliorated post ischemic myocardial inflammation (via modulating MAPK, PI3K/AKT, and PPAR pathways in the compound drug CDDP)

May help simultaneously treat neuropathic pain and possibly prevent analgesic tolerance (via co-targeting NMDAR downstream signaling, GABAA receptors, and blocking TRPA1 in the spinal cord, and reduce prostaglandin E-2 levels)

GABA-A receptor activity may also explain anxiolytic, sedative, and antiepileptic properties in mice

May ameliorate cerebral ischemia nerve damage through multiple mechanisms (via inhibition of neuronal excitotoxicity, blocking of Ca2+ overload, resistance to reactive oxygen species injury in the acute ischemic stage, antagonize blood-brain barrier injury, intervene in inflammatory reactions, prevent neuron excessive death, and promote neurogenesis and angiogenesis in the treatment of ischemic stroke)

Last reviewed by Dr. Abraham Benavides M.D., 03-05-2022

Cannabis Strains High in Borneol

Golden Haze, K13 Haze, Sour Diesel, OG Kush, CBD Skunk Haze, Afghan Kush, Chocolope, Purple Kush, Lemon Skunk

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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.