Unlocking the Science of Cannabis
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As a subscriber, you will be able to access dashboard insights including chemotype overviews and dosing summaries for medical conditions and organ system and receptor breakdowns for cannabinoid and terpene searches. Study lists present important guidance including dosing and chemotype information with the ability to drill down to the published material. And all outputs are fully filterable, to help find just the information you need. Stay up-to-date with the science of cannabis and the endocannabinoid system with CannaKeys.
Here is a small sampling of Borneol studies by title:
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Borneol is a minor terpene in cannabis and is more abundantly found in turmeric, thyme, and ginger, for example.
It is a compound frequently used in Traditional Chinese Medicine as an analgesic and sold in old pharmacies as a dry powder.
Rowantinex is an over-the-counter terpene formula high in pinene, camphene, and borneol.
Recent research elucidates borneol’s potential role as a drug-delivery enhancer via improved blood-brain barrier permeation of drugs for treating ischemia and Alzheimer’s Disease with synergistic effects.
It may also help drugs cross mucous membranes and skin.
Borneol is thought to have anti-inflammatory, anti-oxidant, anti-apoptotic, anti-microbial, and anticoagulant activities and improve energy metabolism.
Concentrated borneol is a pale, white, lump-like solid. Isolated and concentration-dependent borneol is very toxic, with a probable lethal dose of 50-500 mg/kg. This is roughly one teaspoon to one ounce for a 70kg (150lb) person.
Woody, camphor, herbal
Turmeric, thyme, rosemary, ginger
Antibacterial (middle ear infection)
Analgesia (via TRPM8)
Improved drug delivery through the blood-brain barrier (via adenosine receptors)
Rowantinex (i.e., capsules containing pinene, camphene, cineol, fenchone, borneol, and anethole) may increase the expulsion of renal stones after shock-wave lithotripsy (via antispasmodic activity on the smooth muscle in animal models)
It may improve cell sensitivity to anti-cancer chemotherapy and increase cerebral uptake of 5-FU for brain metastasis.
Potentially improve cancer treatment outcomes (via regulating ROS-mediated oxidative damage, MAPKs and PI3K/AKT pathway in human glioma cells, and regulation of HIF-1a expression via mTORC1/eIF4E pathway)
Preclinical anti-hypertensive and vasorelaxant effects improve mice's autonomic impairment and baroreflex dysfunction.
In combination with Tanshinol, borneol may be therapeutic for pressure overload-induced cardiac hypertrophy with anti-atherosclerotic and anti-inflammatory effects (via regulating the mTOR/β-TrcP/NRF2 signal pathway)
Ameliorated post-ischemic myocardial inflammation (via modulating MAPK, PI3K/AKT, and PPAR pathways in the compound drug CDDP)
It may help simultaneously treat neuropathic pain and possibly prevent analgesic tolerance (via co-targeting NMDAR downstream signaling, GABAA receptors, blocking TRPA1 in the spinal cord, and reducing prostaglandin E-2 levels)
GABA-A receptor activity may also explain anxiolytic, sedative, and antiepileptic properties in mice
May ameliorate cerebral ischemia nerve damage through multiple mechanisms (via inhibition of neuronal excitotoxicity, blocking of Ca2+ overload, resistance to reactive oxygen species injury in the acute ischemic stage, antagonizing blood-brain barrier injury, intervention in inflammatory reactions, prevention of neuron excessive death, and promote neurogenesis and angiogenesis in the treatment of ischemic stroke)
Last reviewed by Dr. Abraham Benavides, M.D., 03-05-2022
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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.