Anandamide (AEA) Cannabinoid Research

Anandamide (AEA) Research Dashboard


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CannaKeys has 397 studies associated with Anandamide (AEA).

Here is a small sampling of Anandamide (AEA) studies by title:

Components of the Anandamide (AEA) Research Dashboard

  • Top medical conditions associated with Anandamide (AEA)
  • Proven effects in clinical trials for Anandamide (AEA)
  • Receptors associated with Anandamide (AEA)
  • Individual study details for Anandamide (AEA)

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Overview - Anandamide (AEA)

Description of Anandamide (AEA)

Anandamide was the first endogenous (naturally occurring inside the human body) cannabinoid to be discovered by Raphael Mechoulam in 1995. Mechoulam and his team named the compound combining the Sanskrit word for bliss, "ananda," and the word "amide" describing an organic chemical compound to arrive at the name anandamide. The naturally occurring enzyme fatty acid amide hydrolase (FAAH) breaks down AEA.

Other Names:

Anandamide (N-arachidonyl ethanolamide)

Anandamide (AEA) Properties and Effects

AEA has shown to be involved in a number of social behavior such as play and reward via activation of CB1, anti-inflammatory via PPAR-Gamma, TRPV1 induced vasodilation. Recent discoveries have suggested an associated with oxytocin receptor sites especially in the nucleus accumbens.

Anandamide (AEA) Receptor Binding

Weak affinity for CB1 with a mean Ki 239.2nM. Weak affinity for CB2 with a mean Ki 439.5nM. Binds with TRPV1. Binds with PPARy with an EC50 of 8 μM.

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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.