5F-x Synthetic Cannabinoids Cannabinoid Research

5F-x Synthetic Cannabinoids Research Dashboard

7

Primary Studies

0

Related Studies

7

Total Studies

Clinical Studies

0

Clinical Meta-analyses

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

3

Meta-analyses/Reviews

3

Animal studies

1

Laboratory studies

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CannaKeys has 7 studies associated with 5F-x Synthetic Cannabinoids.

Here is a small sampling of 5F-x Synthetic Cannabinoids studies by title:


Components of the 5F-x Synthetic Cannabinoids Research Dashboard

  • Top medical conditions associated with 5F-x Synthetic Cannabinoids
  • Proven effects in clinical trials for 5F-x Synthetic Cannabinoids
  • Receptors associated with 5F-x Synthetic Cannabinoids
  • Individual study details for 5F-x Synthetic Cannabinoids

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Overview - 5F-x Synthetic Cannabinoids

Description of 5F-x Synthetic Cannabinoids

5F-MDMB-PICA emerged as a novel "herbal" ingredient in drugs of the European recreational market in 2016 (under the names of e.g., "K2", "Spice") and was the most commonly available synthetic cannabinoid in the USA between 2019 and 2020. It is one of the more potent members and is associated with serious adverse health, behavioral effects and deaths.

Other potentially clinically relevant members may include 5F-AMBICA, 5F-AMB (full agonist at CB1), 5F-ADB, 5F-MDMB-PINACA.

5F-x class of synthetic cannabinoids are identified by their 5-flouropentyl chain.

Other Names:

5F-x Family of Synthetic Cannabinoids
5F-MDMB-PICA

IUPAC Name: methyl (2S)-2-[[1-(5-fluoropentyl)indole-3-carbonyl]amino]-3,3-dimethylbutanoate

Molecular Formula: C21H29FN2O3

5F-x Synthetic Cannabinoids Properties and Effects

The use of 5F-MDMB-PICA and other members of this family of synthetic cannabinoids have been associated with:
• Significant hypothermia (Alex; J Krotulski et al., 2021)
• Catalepsy (Alex; J Krotulski et al., 2021)
• High addiction potential especially in adolescents (A. Musa et al., 2020)
• Death (J. Kleis et al., 2020)

5F-x Synthetic Cannabinoids Receptor Binding

The Endocannabinoid system and 5F-MDMB-PICA:
• CB1 full agonist with an IC50 ~2nM (Alex; J Krotulski et al., 2021)
• CB2 full agonist with an EC50~7.5nM (S. Banister et al., 2016)

Endocannabinoidome (eCBome) and 5F-MDMB-PICA:
• Stimulates the release of dopamine in the nucleus accumbens shell of adolescent, but not of adult, test animals. (A. Musa et al., 2020)

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Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.