5F-x Synthetic Cannabinoids Cannabinoid Research

5F-x Synthetic Cannabinoids Research Dashboard

13

Primary Studies

0

Related Studies

13

Total Studies

Clinical Studies

0

Clinical Meta-analyses

0

Double-blind human trials

0

Clinical human trials

Pre-Clinical Studies

6

Meta-analyses/Reviews

5

Animal studies

2

Laboratory studies

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CannaKeys has 13 studies associated with 5F-x Synthetic Cannabinoids.

Here is a small sampling of 5F-x Synthetic Cannabinoids studies by title:


Components of the 5F-x Synthetic Cannabinoids Research Dashboard

  • Top medical conditions associated with 5F-x Synthetic Cannabinoids
  • Proven effects in clinical trials for 5F-x Synthetic Cannabinoids
  • Receptors associated with 5F-x Synthetic Cannabinoids
  • Individual study details for 5F-x Synthetic Cannabinoids

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Overview - 5F-x Synthetic Cannabinoids

Description of 5F-x Synthetic Cannabinoids

5F-MDMB-PICA emerged as a novel "herbal" ingredient in drugs of the European recreational market in 2016 (under the names of e.g., "K2", "Spice") and was the most commonly available synthetic cannabinoid in the USA between 2019 and 2020. It is one of the more potent members and is associated with serious adverse health, behavioral effects and deaths.


Here we focus on 5F-MDMB-PICA.


Other potentially clinically relevant members may include 5F-AMBICA, 5F-AMB (full agonist at CB1), 5F-ADB, 5F-MDMB-PINACA.


5F-x class of synthetic cannabinoids are identified by their 5-flouropentyl chain.

Other Names:

5F-x Family of Synthetic Cannabinoids

5F-MDMB-PICA


IUPAC Name: methyl (2S)-2-[[1-(5-fluoropentyl)indole-3-carbonyl]amino]-3,3-dimethylbutanoate


Molecular Formula: C21H29FN2O3


Source–PubChem

5F-x Synthetic Cannabinoids Properties and Effects

The use of 5F-MDMB-PICA may:


  • Induce significant hypothermia (Alex; J Krotulski et al., 2021)

  • Instill catalepsy (Alex; J Krotulski et al., 2021)

  • High addiction potential especially in adolescents (A. Musa et al., 2020)

  • Cause death (J. Kleis et al., 2020)

5F-x Synthetic Cannabinoids Receptor Binding

The Endocannabinoid system and 5F-MDMB-PICA:


  • CB1 full agonist with an IC50 ~2nM (Alex; J Krotulski et al., 2021)

  • CB2 full agonist with an EC50~7.5nM (S. Banister et al., 2016)


Endocannabinoidome (eCBome) and 5F-MDMB-PICA:


  • Stimulates the release of dopamine in the nucleus accumbens shell of adolescent, but not of adult, test animals. (A. Musa et al., 2020)




Ki legend:



  • Full/strong agonist Ki ~1-9nM

  • Moderate agonist Ki ~10-99nM

  • Weak agonist Ki ~100-999nM

  • Very weak agonist Ki ~1,000-up nM


(The reader is reminded that a smaller Ki is associated with the strongest effects.)

Disclaimers: Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. You should not use the information contained herein for diagnosing a health problem or disease. If using a product, you should read carefully all product packaging. If you have or suspect that you have a medical problem, promptly contact your health care provider.

Information on this site is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over-the-counter medication is also available. Consult your physician, nutritionally oriented health care practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications.