PRIMARY STUDY

Combination of biomarkers for diagnosis of acute kidney injury after cardiopulmonary bypass

Key Findings:  In searching for novel biomarkers to monitor for signs of acute kidney injury (AKI) during and after cardiopulmonary bypass surgery (CPB), this analysis classified different combinations of biomarkers to assess risk, including urinary l-type fatty acid-binding protein (l-FABP), α and π glutathione S-transferases (α-GST and π-GST), urinary neutrophil gelatinase-associated lipocalin (NGAL), and urinary hepcidin and serum cystatin c (CysC).

There was no improvement in risk classification with the combinations of biomarkers used. However, levels of NGAL:Creatinine better categorized high, intermediate, and low-risk groups.