RELATED STUDY
The Effects of Peripubertal THC Exposure in Neurodevelopmental Rat Models of Psychopathology
Key Findings: The offspring of rats who were given Δ9-tetrahydrocannabinol (THC) or methylazoxymethanol acetate (MAM) in pregnancy had alterations in neurodevelopment and in the development of psychopathy, specifically schizophrenia-like phenotype and altered dopaminergic and cannabinoid neurotransmission.
Type of Study: Animal Study
Study Result: Negative
Study Location(s): Canada, Czech Republic, Germany, Italy
Year of Pub: 2023
Cannabinoids Studied: Tetrahydrocannabinol (THC), CP-x Synthetic Cannabinoids, HU-x Synthetic Cannabinoids, WIN-x Synthetic Cannabinoids, Fatty Acid Amide Hydrolase (FAAH), Endocannabinoid (unspecified)
Phytocannabinoid Source: Unspecified
Chemotype: Chemotype I
Receptors Studied: CB1
Ligands Studied: Dopamine
Dosage: THC (5 mg/kg/day)