Oxytocin acts centrally in the brain to improve leaky gut through the vagus nerve and a cannabinoid signaling in rats

Key Findings:  This study looked at gut motility and permeability in rats to determine the role of oxytocin in leaky gut syndromes. Results found oxytocin centrally acts in the brain leading to reduced colon hyperpermeability, and that vagus nerve cholinergic, and therefore cannabinoid 1 receptors, play an important role in gut signaling and regulation. These results may have implications for autism disorder and irritable bowel syndrome.

Type of Study:  Animal Study

Study Result:  Positive

Study Location(s):  Japan

Year of Pub:  2022

Cannabinoids Studied:  Endocannabinoid (unspecified)

Phytocannabinoid Source:  Not Applicable

Receptors Studied:  CB1

Ligands Studied:  Ghrelin, Oxytocin