Key Findings:  Using mixed lymphocyte reaction (MLR) as a model of organ and skin graft rejection in mice found that exposure to CB2 selective agonists prolongs skin graft rejection time, and presents a potential therapeutic target in organ transplant rejection prevention and autoimmune conditions.
Type of Study:  Animal Study
Study Result:  Positive
Study Location(s):  United States
Year of Pub:  2021
Cannabinoids Studied:  Tetrahydrocannabinol (THC), O-x Synthetic Cannabinoids, 2-Arachidonoyl Glycerol (2-AG), Endocannabinoid (unspecified)
Phytocannabinoid Source:  Not Applicable
Receptors Studied:  CB1, CB2
Ligands Studied:  Anti-inflammatory cytokines, Pro-inflammatory cytokines