Herbal Approaches to Pediatric Functional Abdominal Pain

Key Findings:  This review of herbal alternatives to treat pediatric abdominal-pain-related functional gastrointestinal disorders (AP-FGIDs) which include irritable bowel syndrome (IBS), functional dyspepsia (FD), abdominal migraine, and functional abdominal pain (FAP), suggests that herbal remedies are well tolerated and at least match up to placebo in efficacy. They included peppermint oil, Iberogast®, cannabis, fennel, and licorice as herbal treatments. There are currently few studies looking specifically at cannabis for IBS, and the risk of worsening hyperemesis remains a concern.

Type of Study:  Meta-analysis

Study Result:  Inconclusive

Study Location(s):  United States

Year of Pub:  2022

Cannabinoids Studied:  Cannabidiol (CBD), Tetrahydrocannabinol (THC), Cannabinoid (unspecified), Pharma THC

Phytocannabinoid Source:  Unspecified

Receptors Studied:  CB1, CB2, GPCR 55, TRPV1, PPAR - Alpha, PPAR - Gamma

Ligands Studied:  Serotonin

Route of Administration:  Oral (Ingestion)

Link to study