RELATED STUDY
Cutaneous Squamous Cell Carcinoma and Lichen Simplex Chronicus Successfully Treated with Topical Cannabinoid Oil: A Case Report and Summary of Cannabinoids in Dermatology
Key Findings: This case report of a 64-year-old woman with lichen simplex chronicus and squamous cell carcinoma who applied topical 20% cannabidiol. Her lesions were successfully treated within less than 4 weeks, as well as complete regression of several biopsy-confirmed squamous cell carcinomas. The hypothesized mechanism involves the CB1 and CB2 receptors of the endocannabinoid system and their anti-inflammatory properties.
Type of Study: Meta-analysis
Study Sample Size: 1
Study Result: Positive
Study Location(s): United States
Year of Pub: 2022
Cannabinoids Studied: Cannabichromene (CBC), Cannabidiol (CBD), Cannabigerol (CBG), Tetrahydrocannabinol (THC), Cannabinol (CBN), Cannabidiolic Acid (CBD-a), Tetrahydrocannabinolic Acid (THC-a), JWH-x Synthetic Cannabinoids, WIN-x Synthetic Cannabinoids, Anandamide (AEA), 2-Arachidonoyl Glycerol (2-AG), N-Arachidonoyl Dopamine (NADA), Virodhamine (O-AEA), Endocannabinoid (unspecified), Pharma THC, Pharma THC:CBD, Cannabidivarin (CBDV), Palmitoylethanolamide (PEA)
Phytocannabinoid Source: Cannabis Flower derived
Terpenes Studied: ß-Caryophyllene
Receptors Studied: CB1, CB2, GPCR
Dosage: CBD oil (twice daily to the lesion)