Key Findings:  This mouse model of long-term use of CBD oil in Autism Spectrum Disorder (ASD) found a reduction of symptoms of anxiety and repetitive behaviors as well as a link to the mechanism of action within the CB1 receptors, glutamate, and alterations of RNA neurotransmission genes in the treatment group.
Type of Study:  Animal Study
Study Result:  Positive
Study Location(s):  Israel
Year of Pub:  2021
Cannabinoids Studied:  Cannabidiol (CBD), Tetrahydrocannabinol (THC), AM-x Synthetic Cannabinoids, WIN-x Synthetic Cannabinoids, Endocannabinoid (unspecified)
Phytocannabinoid Source:  Cannabis Flower derived
Chemotype:  Chemotype I, Chemotype III
Receptors Studied:  CB1
Ligands Studied:  GABA, Glutamate
Sub-Ratio: THC:CBD 1:25 THC:CBD 1:0
Dosage: CBD:THC (25 mg/kg:1 mg/kg) and THC (1 mg/kg)
Route of Administration:  Oral (Ingestion)