Key Findings:  There is strong evidence that treatment with cannabinoids, specifically cannabidiol, is safe and well-tolerated for many of the common symptoms affecting children with neurodevelopmental disorders.
Type of Study:  Meta-analysis
Study Result:  Positive
Research Location(s):  Australia, Italy
Year of Pub:  2021
Cannabinoids Studied:  Cannabidiol (CBD), Anandamide (AEA), Fatty Acid Amide Hydrolase (FAAH), 2-Arachidonoyl Glycerol (2-AG), Cannabinoid (unspecified), Microbiome
Phytocannabinoid Source:  Unspecified
Chemotype:  Chemotype III
Receptors Studied:  CB1, CB2, GPCR 55, TRPV1, TRPV2, PPAR - Alpha
Ligands Studied:  Acetylcholine, Anti-inflammatory cytokines, Dopamine, GABA, Glutamate, Serotonin, Pro-inflammatory cytokines
Citation:  Kwan Cheung KA, et al. Cannabidiol and Neurodevelopmental Disorders in Children. Front Psychiatry. 2021; 12:643442. doi: 10.3389/fpsyt.2021.643442
Authors:  Kwan Cheung KA, Mitchell MD, Heussler HS