PRIMARY STUDY

The effect of cannabis on urge incontinence in patients with multiple sclerosis: a multicentre, randomised placebo-controlled trial (CAMS-LUTS).

Key Findings:  The CAMS study randomised 630 patients to receive oral administration of cannabis extract, Delta(9)-tetrahydrocannabinol (THC) or matched placebo. All three groups showed a significant reduction symptoms: cannabis extract, 38%; THC, 33%; and placebo, 18%. Both active treatments showed significant effects over placebo. The findings are suggestive of a clinical effect of cannabis on incontinence episodes in patients with MS.