PRIMARY STUDY

An open-label pilot study of cannabis-based extracts for bladder dysfunction in advanced multiple sclerosis

Key Findings:  Urinary urgency, the number and volume of incontinence episodes, frequency, and nocturia all decreased significantly following treatment. Patient self-assessment of pain, spasticity, and quality of sleep improved significantly (PB/0.05, Wilcoxon’s signed rank test) with pain improvement continuing up to median of 35 weeks. There were few troublesome side effects, suggesting that cannabis-based medicinal extracts are a safe and effective treatment for urinary and other problems in patients with advanced MS.