PRIMARY STUDY

Obesity-Related CKD: When Kidneys Get the Munchies

Key Findings:  Various components of the ECS system (e.g. CB1, CB2) are widely distributed in the kidneys especially in podocytes, mesangial cells, and proximal tubule cells. The authors posit that obesity increased endocannabinoid tone, which in turn increase CB1 activation inducing numerous modulators of obesity-related CKD such as increases in appetite, leptin, insulin resistance, obesity related metabolic and hormonal abnormalities for example. CB1 antagonism has shown to improved various health care markers in obesity-related CKD.